Blood–ocular barrier

The blood-ocular barrier is a barrier created by endothelium of capillaries of the retina and iris, ciliary epithelium and retinal pigment epithelium.[1] It is a physical barrier between the local blood vessels and most parts of the eye itself, and stops many substances including drugs from traveling across it.[2] Inflammation can break down this barrier allowing drugs and large molecules to penetrate into the eye.[3] As the inflammation subsides, this barrier usually returns.

It consists of the following components:

See also

References

  1. ^ Peiffer, Robert L.; Petersen-Jones, Simon M. (2001). Small animal ophthalmology: a problem-oriented approach. Elsevier Health Sciences. p. 46. ISBN 9-7807-020-2570-9. http://books.google.co.uk/books?id=a_mP8FbbsPcC&pg=PA46&dq=%22Blood-ocular+barrier%22&hl=en&ei=2z4dTbjqAZSyhAfyrIS3Dg&sa=X&oi=book_result&ct=result&resnum=6&ved=0CD0Q6AEwBTgK#v=onepage&q=%22Blood-ocular%20barrier%22&f=false. 
  2. ^ a b Kramer, Axel; Behrens-Baumann, Wolfgang (2002). Antiseptic prophylaxis and therapy in ocular infections: principles, clinical practice, and infection control. Karger Publishers. p. 72. ISBN 9-7838-055-7316-0. http://books.google.co.uk/books?id=JkQOSAnOIhoC&pg=PA72&dq=%22Blood-ocular+barrier%22+iris&hl=en&ei=-jsdTcqQKI-GhQeqwcW3Dg&sa=X&oi=book_result&ct=result&resnum=4&sqi=2&ved=0CD0Q6AEwAw#v=onepage&q=%22Blood-ocular%20barrier%22%20iris&f=false. 
  3. ^ Giguère, Steeve; Prescott, John F.; Desmond Baggot, J. (2006). Antimicrobial therapy in veterinary medicine. Wiley-Blackwell. p. 366. ISBN 9-7808-138-0656-3. http://books.google.co.uk/books?id=lxmyfSave4IC&pg=PA366&dq=%22Blood-ocular+barrier%22+inflammation&hl=en&ei=0kEdTazpNouChQeE5IC3Dg&sa=X&oi=book_result&ct=result&resnum=6&ved=0CEUQ6AEwBQ#v=onepage&q=%22Blood-ocular%20barrier%22%20inflammation&f=false. 
  4. ^ Coscas, G.; Cunha-Vaz, J.; Loewenstein, A.; Soubrane (2010). Macular Edema: A Practical Approach. Karger Publishers. p. 59. ISBN 9-7838-055-9434-9. http://books.google.co.uk/books?id=TXKwltz-Cz0C&pg=PA59&dq=%22Blood-ocular+barrier%22&hl=en&ei=tkkdTb2_FYqyhAe43KW3Dg&sa=X&oi=book_result&ct=result&resnum=7&sqi=2&ved=0CEgQ6AEwBg#v=onepage&q=%22Blood-ocular%20barrier%22&f=false. 
  5. ^ J. Maggs, David; E. Miller, Paul; Ofri; H. Slatter, Douglas (2008). Slatter's fundamentals of veterinary ophthalmology. Elsevier Health Sciences. p. 455. ISBN 9-7807-216-0561-6. http://books.google.co.uk/books?id=pjJKkwJbLBQC&pg=PA455&dq=%22Blood-ocular+barrier%22+Blood-retinal+barrier&hl=en&ei=bksdTdDeKYGHhQe3q7i3Dg&sa=X&oi=book_result&ct=result&resnum=3&ved=0CDIQ6AEwAg#v=onepage&q=%22Blood-ocular%20barrier%22%20Blood-retinal%20barrier&f=false.